Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases. However, the role of the immunoproteasome in the pathogenesis of immune thrombocytopenia (IT...

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Bibliographic Details
Main Authors: Sheng-hong Du, Yu-jiao Xiang, Lu Liu, Mu Nie, Yu Hou, Ling Wang, Ban-ban Li, Miao Xu, Qing-liang Teng, Jun Peng, Ming Hou, Yan Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
immune thrombocytopenia
immunoproteasome
LMP2
LMP7
FcγRs
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.603278/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.603278/full

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