Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure

Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure

Malaria, an infectious disease caused by the parasite Plasmodium falciparum, causes nearly 435,000 deaths annually worldwide. RIFINs and STEVORs are two variant surface antigen families that are involved in malaria pathogenesis and immune evasion. Recent work has shown that a lack of humoral immunit...

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Bibliographic Details
Main Authors: Albert E. Zhou, Andrea A. Berry, Jason A. Bailey, Andrew Pike, Antoine Dara, Sonia Agrawal, Emily M. Stucke, Amed Ouattara, Drissa Coulibaly, Kirsten E. Lyke, Matthew B. Laurens, Matthew Adams, Shannon Takala-Harrison, Jozelyn Pablo, Algis Jasinskas, Rie Nakajima, Amadou Niangaly, Bourema Kouriba, Abdoulaye K. Kone, J. Alexandra Rowe, Ogobara K. Doumbo, Mahamadou A. Thera, Jigar J. Patel, John C. Tan, Philip L. Felgner, Christopher V. Plowe, Mark A. Travassos
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mSphere
Subjects:
Plasmodium falciparum
RIFIN
STEVOR
malaria
microarrays
peptide
semiconserved domain
severe malaria
variant surface antigen
Online Access:https://doi.org/10.1128/mSphere.00097-19

Internet

https://doi.org/10.1128/mSphere.00097-19

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