Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

Abstract Background Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that both genetic susceptibilities and changes in DNA methylation influence pivotal biological pathways and thereby contribute...

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Bibliographic Details
Main Authors: Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Celia M. T. Greenwood, Marie Hudson
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Medical Genomics
Subjects:
Systemic sclerosis
Whole-genome bisulfite sequencing
Differential methylation
Pathway analysis
SNP-CpG association
Online Access:http://link.springer.com/article/10.1186/s12920-019-0602-8

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http://link.springer.com/article/10.1186/s12920-019-0602-8

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