Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the skin penetration of tacrolimus formulated in tNGs with a commercial 0.1% tacrol...

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Bibliographic Details
Main Authors: Fiorenza Rancan, Hildburg Volkmann, Michael Giulbudagian, Fabian Schumacher, Jessica Isolde Stanko, Burkhard Kleuser, Ulrike Blume-Peytavi, Marcelo Calderón, Annika Vogt
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
tacrolimus formulation
nanogels
skin penetration
drug delivery
human excised skin
Jurkat cells
Online Access:https://www.mdpi.com/1999-4923/11/8/394

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https://www.mdpi.com/1999-4923/11/8/394

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