Investigation of Somatic Mutations in Human Brains Targeting Genes Associated With Parkinson's Disease

Investigation of Somatic Mutations in Human Brains Targeting Genes Associated With Parkinson's Disease

Background: Somatic single nucleotide variant (SNV) mutations occur in neurons but their role in synucleinopathies is unknown.Aim: We aimed to identify disease-relevant low-level somatic SNVs in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying LRRK2 G2019S, whose...

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Bibliographic Details
Main Authors: Melissa Leija-Salazar, Alan Pittman, Katya Mokretar, Huw Morris, Anthony H. Schapira, Christos Proukakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
SNCA
synuclein
Parkinson's disease
somatic mutation
targeted sequencing
synucleinopathies
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.570424/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.570424/full

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