Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of organic anion transporting polypeptide 1B1 (OATP1B1) and cytochrome P450 (P450) probe substrates and their phase I metabolites in human plasma was developed. The OATP1B1 (pita...

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Bibliographic Details
Main Authors: Jae-Kyung Heo, Hyun-Ji Kim, Ga-Hyun Lee, Boram Ohk, Sangkyu Lee, Kyung-Sik Song, Im Sook Song, Kwang-Hyeon Liu, Young-Ran Yoon
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceutics
Subjects:
cytochrome P450
drug interaction
liquid chromatography-tandem mass spectrometry
organic anion transporting polypeptide
pharmacokinetics
Online Access:http://www.mdpi.com/1999-4923/10/3/79

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http://www.mdpi.com/1999-4923/10/3/79

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