Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration

Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration

Background: Rapid-acting antidepressants ketamine and (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) have overcome some of the major limitations of classical antidepressants. However, little is known about sex-specific differences in the behavioral and molecular effects of ketamine and (2R,6R)-HNK in rode...

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Bibliographic Details
Main Authors: David P. Herzog, Ratnadevi M. Mellema, Floortje Remmers, Beat Lutz, Marianne B. Müller, Giulia Treccani
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
ketamine
hydroxynorketamine
antidepressant
rapid-acting
sex difference
bdnf
activated neurons
behavior
Online Access:https://www.mdpi.com/1422-0067/21/6/2142

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https://www.mdpi.com/1422-0067/21/6/2142

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