Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools

Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools

IntroductionCommon Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mat...

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Bibliographic Details
Main Authors: Lucía del Pino-Molina, Eduardo López-Granados, Quentin Lecrevisse, Juan Torres Canizales, Martín Pérez-Andrés, Elena Blanco, Marjolein Wentink, Carolien Bonroy, Jana Nechvatalova, Tomas Milota, Anne-Kathrin Kienzler, Jan Philippé, Ana E. Sousa, Mirjam van der Burg, Tomas Kalina, Jacques J.M. van Dongen, Alberto Orfao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
CVID
Pre-GC B-cell tube
pre-GC maturation pathway
expression markers
EuroFlow standardization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.603972/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.603972/full

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