Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

Optimization of Innovative Three-Dimensionally-Structured Hybrid Vesicles to Improve the Cutaneous Delivery of Clotrimazole for the Treatment of Topical Candidiasis

New three-dimensionally-structured hybrid phospholipid vesicles, able to load clotrimazole in a high amount (10 mg/mL), were obtained for the first time in this work by significantly reducing the amount of water (≤10%), which was replaced with a mixture of glycerol and ethanol (≈...

Full description

Bibliographic Details
Main Authors: Maria Letizia Manca, Iris Usach, José Esteban Peris, Antonella Ibba, Germano Orrù, Donatella Valenti, Elvira Escribano-Ferrer, Juan Carmelo Gomez-Fernandez, Francisco José Aranda, Anna Maria Fadda, Maria Manconi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
phospholipid vesicles
clotrimazole
co-solvents
skin delivery
fungal infections
<i>Candida albicans</i>
Online Access:https://www.mdpi.com/1999-4923/11/6/263

Internet

https://www.mdpi.com/1999-4923/11/6/263

Similar Items