Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium

Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium

Hammerhead ribozymes are one of the most studied classes of ribozymes so far, from both the structural and biochemical point of views. The activity of most hammerhead ribozymes is cation-dependent. Mg<sup>2+</sup> is one of the most abundant divalent cations in the cell and therefore pla...

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Bibliographic Details
Main Authors: Mohammad Reza Naghdi, Emilie Boutet, Clarisse Mucha, Jonathan Ouellet, Jonathan Perreault
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Non-Coding RNA
Subjects:
manganese
magnesium
cation
rna variants
c6 hammerhead variants
a6
Online Access:https://www.mdpi.com/2311-553X/6/1/14

Internet

https://www.mdpi.com/2311-553X/6/1/14

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