PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.

<h4>Background</h4>Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized.<h4>Methods</h4>We created a genetic risk score (GRS) for PCSK9 using four single nucleotid...

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Bibliographic Details
Main Authors: Aeron M Small, Jennifer E Huffman, Derek Klarin, Julie A Lynch, Themistocles Assimes, Scott DuVall, Yan V Sun, Labiba Shere, Pradeep Natarajan, Michael Gaziano, Daniel J Rader, Peter W F Wilson, Philip S Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Juan P Casas, Scott M Damrauer, VA Million Veteran Program
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239752

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https://doi.org/10.1371/journal.pone.0239752

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