The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.

Bibliographic Details
Main Authors: Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D. Otto, Debora Casandra, Sandhya Boyapalle, Swamy R. Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24814-1

Internet

https://doi.org/10.1038/s41467-021-24814-1

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