The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.
Bibliographic Details
Main Authors: |
Min Zhang,
Chengqi Wang,
Jenna Oberstaller,
Phaedra Thomas,
Thomas D. Otto,
Debora Casandra,
Sandhya Boyapalle,
Swamy R. Adapa,
Shulin Xu,
Katrina Button-Simons,
Matthew Mayho,
Julian C. Rayner,
Michael T. Ferdig,
Rays H. Y. Jiang,
John H. Adams |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2021-07-01
|
Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-021-24814-1
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