The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24814-1 |
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doaj-6cf614cb2d744e3081e92819ff983c472021-08-01T11:38:29ZengNature Publishing GroupNature Communications2041-17232021-07-0112111510.1038/s41467-021-24814-1The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasiteMin Zhang0Chengqi Wang1Jenna Oberstaller2Phaedra Thomas3Thomas D. Otto4Debora Casandra5Sandhya Boyapalle6Swamy R. Adapa7Shulin Xu8Katrina Button-Simons9Matthew Mayho10Julian C. Rayner11Michael T. Ferdig12Rays H. Y. Jiang13John H. Adams14Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaWellcome Sanger Institute, Wellcome Genome CampusCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaEck Institute for Global Health, Department of Biological Sciences, University of Notre DameWellcome Sanger Institute, Wellcome Genome CampusWellcome Sanger Institute, Wellcome Genome CampusCambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical CampusCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South FloridaRepeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.https://doi.org/10.1038/s41467-021-24814-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams |
| spellingShingle |
Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite Nature Communications |
| author_facet |
Min Zhang Chengqi Wang Jenna Oberstaller Phaedra Thomas Thomas D. Otto Debora Casandra Sandhya Boyapalle Swamy R. Adapa Shulin Xu Katrina Button-Simons Matthew Mayho Julian C. Rayner Michael T. Ferdig Rays H. Y. Jiang John H. Adams |
| author_sort |
Min Zhang |
| title |
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| title_short |
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| title_full |
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| title_fullStr |
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| title_full_unstemmed |
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| title_sort |
apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-07-01 |
| description |
Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance. |
| url |
https://doi.org/10.1038/s41467-021-24814-1 |
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