Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial

Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial

Background: N-acetylcysteine (NAC) has been used as a classic treatment for hepatotoxicity induced by N- acetyl-p-benzoquinone imine (NAPQI) as a metabolite of acetaminophen. However, cimetidine theoretically can reduce the production of toxic metabolites through the inhibition of cytochrome p450,...

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Bibliographic Details
Main Authors: Mohsen Ebrahimi, Seyed Reza Mousavi, Alireza Ghassemi Toussi, Hamidreza Reihani, Farhad Bagherian
Format: Article
Language:English
Published: Electronic Physician 2015-10-01
Series:Electronic Physician
Subjects:
acetaminophen
acetylcysteine
cimetidine
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623788/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623788/

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