A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice.

While there are a number of licensed veterinary DNA vaccines, to date, none have been licensed for use in humans. Here, we demonstrate that a novel technology designed to enhance the immunogenicity of DNA vaccines protects against lethal herpes simplex virus 2 (HSV-2) challenge in a murine model. Po...

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Bibliographic Details
Main Authors: Julie L Dutton, Bo Li, Wai-Ping Woo, Joshua O Marshak, Yan Xu, Meei-li Huang, Lichun Dong, Ian H Frazer, David M Koelle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3789751?pdf=render