Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1

Background/Aims: The imbalance between excitation and inhibition is a defining feature of epilepsy. GluA1 is an AMPA receptor subunit that can strengthen excitatory synaptic transmission when upregulated in the postsynaptic membrane, which has been implicated in the pathogenesis of epilepsy. cGKII,...

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Bibliographic Details
Main Authors: Juan Gu, Xin Tian, Wei Wang, Qin Yang, Peijia Lin, Yuanlin Ma, Yan Xiong, Demei Xu, Yanke Zhang, Yong Yang, Shanshan Lu, Zijun Lin, Jing Luo, Fei Xiao, Xuefeng Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
4-aminopyridine
CGKII
Epilepsy
GluA1
Pilocarpine
Online Access:https://www.karger.com/Article/FullText/488419

Internet

https://www.karger.com/Article/FullText/488419

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