Two-Player Game in a Complex Landscape: 26S Proteasome, PKA, and Intracellular Calcium Concentration Modulate Mammalian Sperm Capacitation by Creating an Integrated Dialogue—A Computational Analysis

Two-Player Game in a Complex Landscape: 26S Proteasome, PKA, and Intracellular Calcium Concentration Modulate Mammalian Sperm Capacitation by Creating an Integrated Dialogue—A Computational Analysis

Recent experimental findings suggest the involvement of the 26S proteasome, the main protease active in eukaryotic cells, in the process that leads mammalian sperm to become fully fertile, so-called capacitation. Unfortunately, its role in male gametes signaling is still far from being completely un...

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Bibliographic Details
Main Authors: Angela Taraschi, Costanza Cimini, Giulia Capacchietti, Marina Ramal-Sanchez, Luca Valbonetti, Juliana Machado-Simoes, Fadl Moussa, Israiel Tagaram, Samia Mokh, Mohamad Al Iskandarani, Alessia Colosimo, Barbara Barboni, Nicola Bernabò
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
male gametes
sperm capacitation
protein phosphorylation
biological network
computational modeling
sperm signaling
Online Access:https://www.mdpi.com/1422-0067/21/17/6256

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https://www.mdpi.com/1422-0067/21/17/6256

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