Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Abstract Background Cell-type-specific genes exhibit heterogeneity in genomic contexts and may be subject to different epigenetic regulations through different gene transcriptional processes depending on the cell type involved. The gene-body regions (GBRs) of some cardiomyocyte (CM)-specific genes a...

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Bibliographic Details
Main Authors: Mayumi Oda, Shunichi Wakabayashi, N. Ari Wijetunga, Shinsuke Yuasa, Hirokazu Enomoto, Ruri Kaneda, Sung Han Yoon, Nishant Mittal, Qiang Jing, Masako Suzuki, John M. Greally, Keiichi Fukuda, Shinji Makino
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Genomics
Subjects:
DNA methylation
Gene length
5-hydroxymethylation
Cardiomyocytes
Epigenome
Online Access:http://link.springer.com/article/10.1186/s12864-018-4752-4

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http://link.springer.com/article/10.1186/s12864-018-4752-4

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