Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)
Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise M...
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Format: | Article |
Language: | English |
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Elsevier
2018-06-01
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Series: | Contemporary Clinical Trials Communications |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865417302016 |
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doaj-6d05d96851bc4a0f862882bfc7632808 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diana Silva Rita Moreira Oksana Sokhatska Marília Beltrão Tiago Montanha Vanessa Garcia-Larsen Rodrigo Villegas Milton Severo Andreia Pizarro Mariana Pinto Carla Martins Ana Duarte Luís Delgado João Rufo Inês Paciência João Paulo Teixeira Carla Costa Pedro Moreira Joana Carvalho André Moreira |
spellingShingle |
Diana Silva Rita Moreira Oksana Sokhatska Marília Beltrão Tiago Montanha Vanessa Garcia-Larsen Rodrigo Villegas Milton Severo Andreia Pizarro Mariana Pinto Carla Martins Ana Duarte Luís Delgado João Rufo Inês Paciência João Paulo Teixeira Carla Costa Pedro Moreira Joana Carvalho André Moreira Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) Contemporary Clinical Trials Communications |
author_facet |
Diana Silva Rita Moreira Oksana Sokhatska Marília Beltrão Tiago Montanha Vanessa Garcia-Larsen Rodrigo Villegas Milton Severo Andreia Pizarro Mariana Pinto Carla Martins Ana Duarte Luís Delgado João Rufo Inês Paciência João Paulo Teixeira Carla Costa Pedro Moreira Joana Carvalho André Moreira |
author_sort |
Diana Silva |
title |
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) |
title_short |
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) |
title_full |
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) |
title_fullStr |
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) |
title_full_unstemmed |
Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial) |
title_sort |
meal-exercise challenge and physical activity reduction impact on immunity and inflammation (meriit trial) |
publisher |
Elsevier |
series |
Contemporary Clinical Trials Communications |
issn |
2451-8654 |
publishDate |
2018-06-01 |
description |
Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Methods: /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. Results: A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction. Conclusion: The use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity. Keywords: Allostatic load, Physical inactivity, Meal, Exercise challenge |
url |
http://www.sciencedirect.com/science/article/pii/S2451865417302016 |
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doaj-6d05d96851bc4a0f862882bfc76328082020-11-25T01:59:28ZengElsevierContemporary Clinical Trials Communications2451-86542018-06-0110177189Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)Diana Silva0Rita Moreira1Oksana Sokhatska2Marília Beltrão3Tiago Montanha4Vanessa Garcia-Larsen5Rodrigo Villegas6Milton Severo7Andreia Pizarro8Mariana Pinto9Carla Martins10Ana Duarte11Luís Delgado12João Rufo13Inês Paciência14João Paulo Teixeira15Carla Costa16Pedro Moreira17Joana Carvalho18André Moreira19Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; Serviço de Imunoalergologia, Centro Hospitalar São João, EPE, Porto, Portugal; Corresponding author. Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro 4200-309 Porto, Portugal.Faculty of Nutrition and Food Sciences University of Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, PortugalResearch Centre in Physical Activity, Health and Leisure - Faculty of Sports, Porto, PortugalDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USASchool of Public Health, University of Chile, ChileEPIUnit – Institute of Public Health, University of Porto, Porto, PortugalResearch Centre in Physical Activity, Health and Leisure - Faculty of Sports, Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; Faculty of Nutrition and Food Sciences University of Porto, PortugalServiço de Imunoalergologia, Centro Hospitalar São João, EPE, Porto, PortugalDepartment of Environmental Health, Portuguese National Institute of Health, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; Serviço de Imunoalergologia, Centro Hospitalar São João, EPE, Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; EPIUnit – Institute of Public Health, University of Porto, Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; EPIUnit – Institute of Public Health, University of Porto, Porto, PortugalDepartment of Environmental Health, Portuguese National Institute of Health, PortugalDepartment of Environmental Health, Portuguese National Institute of Health, PortugalFaculty of Nutrition and Food Sciences University of Porto, PortugalResearch Centre in Physical Activity, Health and Leisure - Faculty of Sports, Porto, PortugalBasic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; Serviço de Imunoalergologia, Centro Hospitalar São João, EPE, Porto, Portugal; EPIUnit – Institute of Public Health, University of Porto, Porto, PortugalBackground: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. Methods: /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. Results: A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept similar. During physical inactivity induction, 31% reached the target of 50% reduction in mean step number and 77% reached a 30% reduction. Conclusion: The use of a pre-exercise meal to modulate immune response and the understanding of the immunological impact of physical inactivity might help to establish future recommendations on how to practice exercise in a safer way and to recognize the potential impact of inactivity. Keywords: Allostatic load, Physical inactivity, Meal, Exercise challengehttp://www.sciencedirect.com/science/article/pii/S2451865417302016 |