Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activi...

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Bibliographic Details
Main Authors: Jan Jakub Lica, Miłosz Wieczór, Grzegorz Jan Grabe, Mateusz Heldt, Marta Jancz, Majus Misiak, Katarzyna Gucwa, Wioletta Brankiewicz, Natalia Maciejewska, Anna Stupak, Maciej Bagiński, Krzysztof Rolka, Andrzej Hellmann, Andrzej Składanowski
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
cell culture density-dependent cytological stage profile
primitive acute myeloid leukemia cellular stages
primitive cancer cellular stages
drug screening platform
effective drug concentration
selectivity index
Online Access:https://www.mdpi.com/1422-0067/22/9/4931

Internet

https://www.mdpi.com/1422-0067/22/9/4931

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