Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activi...

Full description

Bibliographic Details
Main Authors:	Jan Jakub Lica, Miłosz Wieczór, Grzegorz Jan Grabe, Mateusz Heldt, Marta Jancz, Majus Misiak, Katarzyna Gucwa, Wioletta Brankiewicz, Natalia Maciejewska, Anna Stupak, Maciej Bagiński, Krzysztof Rolka, Andrzej Hellmann, Andrzej Składanowski
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	International Journal of Molecular Sciences
Subjects:	cell culture density-dependent cytological stage profile primitive acute myeloid leukemia cellular stages primitive cancer cellular stages drug screening platform effective drug concentration selectivity index
Online Access:	https://www.mdpi.com/1422-0067/22/9/4931

Similar Items

Cryptographic primitives based on cellular transformations
by: B.V. Izotov
Published: (2003-11-01)

Analysis Algorithms of Primitiveness of the Directed Graphs
by: S.N. Kyazhin, et al.
Published: (2012-03-01)

LOCALLY PRIMITIVELY UNIVERSAL FORMS AND THE PRIMITIVE COUNTERPART TO THE FIFTEEN THEOREM
by: Gunawardana, Beruwalage Lakshika Kumari
Published: (2020)

La violence de l'échange : du contenu de l'échange entre le sujet exclu et l'institution
by: Macia, Chantal
Published: (2009)

About Primitiveness of Cyclic Matrices
by: Yana Eduardovna Avezova
Published: (2015-03-01)

A new appearance on the face of things : retelling the Primitive Methodist creation narrative
by: Woolley, Timothy Robert
Published: (2013)

MACOP Modular Architecture with Control Primitives
by: Tim eWaegeman, et al.
Published: (2013-07-01)

Ostéomyélite chronique primitive de la mandibule
by: Mohamed Sahli, et al.
Published: (2020-09-01)

Development of an Interferon Bioassay and Primitive Endoderm Cell Lines to Study Lineage Specification During Early Bovine Embryogenesis
by: Mccoski, Sarah R.
Published: (2016)

Model selection for the extraction of movement primitives
by: Dominik M Endres, et al.
Published: (2013-12-01)

Primitive Neuroectodermal Tumor Presenting with Diffuse Leptomeningeal Involvement in a 55-Year-Old Woman: A Case Report and Brief Summary of Current Diagnostic Tests and Treatment
by: Navya Kalidindi, et al.
Published: (2014-07-01)

Co-existence of persistent primitive trigeminal artery and another primitive carotid-basilar anastomosis associated with segmental agenesis of the ipsilateral internal carotid artery: a case report
by: Kenyu Hayashi, et al.
Published: (2018-05-01)

SYNTHESIS OF PRIMITIVE MATRICES OVER A FINITE GALOIS FIELDS AND THEIR APPLICATIONS
by: A.J. Beletsky, et al.
Published: (2012-10-01)

Primary spinal primitive neuroectodermal tumor on MR imaging
by: Prashant J Thoriya, et al.
Published: (2015-10-01)

Primitive neuro-ectodermal tumor of the lung in an adult
by: Gaude G, et al.
Published: (2009-01-01)

On the distribution of primitive roots that are $(k,r)$-integers
by: Teerapat Srichan, et al.
Published: (2019-12-01)

On the distribution of primitive roots that are $(k,r)$-integers
by: Teerapat Srichan, et al.
Published: (2019-12-01)

Renal Primitive Neuroectodermal Tumor
by: Hüseyin Çelik, et al.
Published: (2017-06-01)

Testing Primitive Polynomials for Generalized Feedback Shift Register Random Number Generators
by: Lian, Guinan
Published: (2005)

A Peripheral Primitive Neuro-ectodermal Tumor (pPNET) of Larynx
by: Raman Wadhera, et al.
Published: (2020-07-01)

Renal primitive neuroectodermal tumor: does age at diagnosis impact outcomes?
by: Mahkameh Zare, et al.
Published: (2012-01-01)

A Peripheral Primitive Neuro-ectodermal Tumor (pPNET) of Larynx
by: Raman Wadhera, et al.
Published: (2018-04-01)

Primary primitive neuroectodermal tumor of the orbit
by: Das Dipankar, et al.
Published: (2009-01-01)

THE TABULAR OF CRYPTOGRAPHIC PRIMITIVES OF NONLINEAR SUBSTITUTIONS
by: A. Beletsky
Published: (2015-03-01)

Exponent-critical primitive graphs and the Kronecker product
by: Olga O'Mahony, et al.
Published: (2019-10-01)

Primitive Ideal Space of Ultragraph $C^*$-algebras
by: Mostafa Imanfar, et al.
Published: (2019-07-01)

Primitive Neuroectodermal Tumor of the Uterus: A Case Report
by: Tzu-Chen Yeh, et al.
Published: (2005-03-01)

The minimum exponent of the primitive digraphs on the given number of arcs
by: Jolanta Rosiak
Published: (2004-01-01)

Cervical intraspinal extradural primitive neuroectodermal tumour in an adult
by: Gogou Pinelopi V, et al.
Published: (2014-08-01)

Primitive neuroectodermal tumor of prostate
by: Kumar Vikash, et al.
Published: (2008-07-01)

Primary renal primitive neuroectodermal tumor: A rare presentation
by: V Goel, et al.
Published: (2015-01-01)

Evaluation of cryptographic primitives security based on proximity to the Latin square
by: Vladimir V. Palagushin, et al.
Published: (2016-04-01)

Design and analysis of distributed primitives for mobile ad hoc networks
by: Chen, Yu
Published: (2006)

Spermiogenesis, Stages of Seminiferous Epithelium and Variations in Seminiferous Tubules during Active States of Spermatogenesis in Yangzhou Goose Ganders
by: Muhammad Faheem Akhtar, et al.
Published: (2020-03-01)

Projection-primitive P-Ehresmann semigroups
by: Shoufeng Wang
Published: (2021-05-01)

First report of a primitive neuroectodermal tumor of the bladder in a newborn
by: L. Orbegoso-Celis, et al.
Published: (2021-01-01)

Psychological primitives can make sense of biopsychosocial factor complexity in psychopathology
by: Joseph C. Franklin
Published: (2019-10-01)

Extraneural Supratentorial Primitive Neuroectodermal Tumor Metastasis: An Adult Case Report
by: Nidhal Matar, et al.
Published: (2017-06-01)

On Primitivity and the Unital Full Free Product of Finite Dimensional C*-algebras
by: Torres Ayala, Francisco
Published: (2012)

First report of a primitive neuroectodermal tumor of the bladder in a newborn
by: Orbegoso-Celis, L., et al.
Published: (2021)