Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model

Pan-Sigma Receptor Modulator RC-106 Induces Terminal Unfolded Protein Response In <i>In Vitro</i> Pancreatic Cancer Model

Pancreatic cancer (PC) remains one of the most lethal cancers worldwide. Sigma receptors (SRs) have been proposed as cancer therapeutic targets. Their main localization suggests they play a potential role in ER stress and in the triggering of the unfolded protein response (UPR). Here, we investigate...

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Bibliographic Details
Main Authors: Michela Cortesi, Alice Zamagni, Sara Pignatta, Michele Zanoni, Chiara Arienti, Daniela Rossi, Simona Collina, Anna Tesei
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
sigma receptors
UPR
pancreatic cancer
ER stress
ROS
gatekeepers
Online Access:https://www.mdpi.com/1422-0067/21/23/9012

Internet

https://www.mdpi.com/1422-0067/21/23/9012

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