HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells

HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells

Poly(ADP‐ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However, there is a need to understand the molecular mechanisms of resistance to PARP1 inhibitors. Expression of HMGA2 in cancer is associated with poor...

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Bibliographic Details
Main Authors: Sabine Hombach‐Klonisch, Forouh Kalantari, Manoj Reddy Medapati, Suchitra Natarajan, Sai Nivedita Krishnan, Aditya Kumar‐Kanojia, Thatchawan Thanasupawat, Farhana Begum, Fred Y. Xu, Grant M. Hatch, Marek Los, Thomas Klonisch
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Molecular Oncology
Subjects:
HMGA2
olaparib
PARP1
PARP1 trapping
PARylation
Online Access:https://doi.org/10.1002/1878-0261.12390

Internet

https://doi.org/10.1002/1878-0261.12390

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