Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.

Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.

Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy cells, by contrast...

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Bibliographic Details
Main Authors: James W Wells, Christopher H Evans, Milcah C Scott, Barbara C Rütgen, Timothy D O'Brien, Jaime F Modiano, Goran Cvetkovic, Slobodan Tepic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23365669/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23365669/?tool=EBI

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