A Single, Acute Astragaloside IV Therapy Protects Cardiomyocyte Through Attenuating Superoxide Anion-Mediated Accumulation of Autophagosomes in Myocardial Ischemia-Reperfusion Injury

A Single, Acute Astragaloside IV Therapy Protects Cardiomyocyte Through Attenuating Superoxide Anion-Mediated Accumulation of Autophagosomes in Myocardial Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion (I/R) injury, characterized by myocardial cell death (e.g., apoptosis) and generation of reactive oxygen species (ROS) such as superoxide (O2·−) and hydrogen peroxide (H2O2), is a serious threat to human health and property. Saponin astragaloside IV (ASIV), extracted...

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Bibliographic Details
Main Authors: Kai-yu Huang, Yong-wei Yu, Shuai Liu, Ying-ying Zhou, Jin-sheng Wang, Yang-pei Peng, Kang-ting Ji, Yang-jing Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV
myocardial ischemia-reperfusion
superoxide
autophagy
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.642925/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.642925/full

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