R-Spondin1 enhances wnt signaling and decreases weight loss in short bowel syndrome zebrafish

R-Spondin1 enhances wnt signaling and decreases weight loss in short bowel syndrome zebrafish

Background: R-spondins, including R-spondin 1 (RSPO1), are a family of Wnt ligands that help to activate the canonical Wnt/β-catenin pathway, which is critical for intestinal epithelial cell proliferation and maintenance of intestinal stem cells. This proliferation underpins the epithelial expansion...

Full description

Bibliographic Details
Main Authors: Kathryn M. Maselli, Gabriel Levin, Kristin M. Gee, Elisabeth J. Leeflang, Ana Claudia O. Carreira, Mari Cleide Sogayar, Tracy C. Grikscheit
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Short bowel syndrome
Intestinal adaptation
Zebrafish
Wnt
R-spondin1
Cyclin D1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820301849

Internet

http://www.sciencedirect.com/science/article/pii/S2405580820301849

Similar Items