The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity...

Full description

Bibliographic Details
Main Authors: Ron Firestein, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, Jennifer Campbell, Anupama Bhimavarapu, Sandra Luikenhuis, Rafael de Cabo, Charles Fuchs, William C Hahn, Leonard P Guarente, David A Sinclair
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2289879?pdf=render

Internet

http://europepmc.org/articles/PMC2289879?pdf=render

Similar Items