Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Abstract Background The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells. Our previous studies showed that in encephalitogenic T cells, α7 nAChR expression is upregulated and that activation of the cholinergic...

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Bibliographic Details
Main Authors: Tehila Mizrachi, Oshrit Marsha, Karen Brusin, Yael Ben-David, Ganesh A. Thakur, Adi Vaknin-Dembinsky, Millet Treinin, Talma Brenner
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
α7 Nicotinic acetylcholine receptor
Selective allosteric agonist for α7 nAChR
Multiple sclerosis
B cells
Central nervous system inflammation
Immune cholinergic system
Online Access:https://doi.org/10.1186/s12974-021-02149-4

Internet

https://doi.org/10.1186/s12974-021-02149-4

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