Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
Pei et al. explore the mechanism underlying growth of mutant huntingtin inclusions in yeast cells and show that growth occurs through random collision and incorporation of mutant huntingtin aggregates into a phase-separated condensate. They show that there is a small inner core which is structurally...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02460-z |