LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1...

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Bibliographic Details
Main Authors: Björn Koos, Eva Lotta Moderegger, Katharina Rump, Hartmuth Nowak, Katrin Willemsen, Caroline Holtkamp, Patrick Thon, Michael Adamzik, Tim Rahmel
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
sepsis
mitochondrial DNA
methylation
Online Access:https://www.mdpi.com/2073-4409/9/10/2282

Internet

https://www.mdpi.com/2073-4409/9/10/2282

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