Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.

Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.

BACKGROUND: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. It is controversial whether statin and calcium channel blockers (CCBs) has an inhibitory effect on the expansion of AAA. Some studies reported that CCBs have an inhibitory effect on Rho-kinase activity. Rho-kinase pl...

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Bibliographic Details
Main Authors: Kikuyo Takahashi, Yasuharu Matsumoto, Zhulanqiqige Do e, Masanori Kanazawa, Kimio Satoh, Takuya Shimizu, Akira Sato, Yoshihiro Fukumoto, Hiroaki Shimokawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742630?pdf=render

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http://europepmc.org/articles/PMC3742630?pdf=render

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