Genomic Mechanisms Governing Mineral Homeostasis and the Regulation and Maintenance of Vitamin D Metabolism

ABSTRACT Our recent genomic studies identified a complex kidney‐specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1, as well as suppression by FGF23 and 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3]. The tissue...

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Bibliographic Details
Main Authors: J Wesley Pike, Seong Min Lee, Nancy A Benkusky, Mark B Meyer
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10433