Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are needed. Bevirimat was developed by chemical modificat...

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Bibliographic Details
Main Authors: Luis M. Bedoya, Manuela Beltrán, Javier García-Pérez, Patricia Obregón-Calderón, Oliver Callies, Ignacio A. Jímenez, Isabel L. Bazzocchi, José Alcamí
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
HIV-1
antiretrovirals
maturation
triterpenoids
lupanes
promiscuous compounds
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00358/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00358/full

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