Humanized-Single Domain Antibodies (VH/V<sub>H</sub>H) that Bound Specifically to<em> Naja kaouthia</em> Phospholipase A2 and Neutralized the Enzymatic Activity

Humanized-Single Domain Antibodies (VH/V<sub>H</sub>H) that Bound Specifically to<em> Naja kaouthia</em> Phospholipase A2 and Neutralized the Enzymatic Activity

<em>Naja kaouthia</em> (monocled cobra) venom contains many isoforms of secreted phospholipase A2 (sPLA<sub>2</sub>). The PLA<sub>2</sub> exerts several pharmacologic and toxic effects in the snake bitten subject, de...

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Bibliographic Details
Main Authors: Wanpen Chaicumpa, Nitat Sookrung, Kunan Bangphoomi, Charnwit Chavanayarn, Jeeraphong Thanongsaksrikul, Kanyarat Thueng-in
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Toxins
Subjects:
snake bite
snake venom
phospholipase A2 (PLA<sub>2</sub>)
single domain antibody (SdAb)
VH/V<sub>H</sub>H
homology modeling
molecular docking
Online Access:http://www.mdpi.com/2072-6651/4/7/554

Internet

http://www.mdpi.com/2072-6651/4/7/554

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