Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations f...

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Bibliographic Details
Main Authors: Gengjie Jia, Yu Li, Hanxin Zhang, Ishanu Chattopadhyay, Anders Boeck Jensen, David R. Blair, Lea Davis, Peter N. Robinson, Torsten Dahlén, Søren Brunak, Mikael Benson, Gustaf Edgren, Nancy J. Cox, Xin Gao, Andrey Rzhetsky
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13455-0

Internet

https://doi.org/10.1038/s41467-019-13455-0

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