Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations f...

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Main Authors:	Gengjie Jia, Yu Li, Hanxin Zhang, Ishanu Chattopadhyay, Anders Boeck Jensen, David R. Blair, Lea Davis, Peter N. Robinson, Torsten Dahlén, Søren Brunak, Mikael Benson, Gustaf Edgren, Nancy J. Cox, Xin Gao, Andrey Rzhetsky
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13455-0

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spelling	doaj-6d34b36c86004f14891b25d4276eebf52021-05-11T12:08:13ZengNature Publishing GroupNature Communications2041-17232019-12-0110111110.1038/s41467-019-13455-0Estimating heritability and genetic correlations from large health datasets in the absence of genetic dataGengjie Jia0Yu Li1Hanxin Zhang2Ishanu Chattopadhyay3Anders Boeck Jensen4David R. Blair5Lea Davis6Peter N. Robinson7Torsten Dahlén8Søren Brunak9Mikael Benson10Gustaf Edgren11Nancy J. Cox12Xin Gao13Andrey Rzhetsky14Department of Medicine, Institute of Genomics and Systems Biology, University of ChicagoComputational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)Department of Medicine, Institute of Genomics and Systems Biology, University of ChicagoDepartment of Medicine, Institute of Genomics and Systems Biology, University of ChicagoInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiDepartment of Pediatrics, University of California San FranciscoDivision of Genetic Medicine, Vanderbilt UniversityJackson Laboratory for Genomic MedicineDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of CopenhagenCentre for Individualized Medicine, Department of Pediatrics, Linkoping UniversityDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDivision of Genetic Medicine, Vanderbilt UniversityComputational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)Department of Medicine, Institute of Genomics and Systems Biology, University of ChicagoDisease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations for thousands of disease pairs.https://doi.org/10.1038/s41467-019-13455-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky
spellingShingle	Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky Estimating heritability and genetic correlations from large health datasets in the absence of genetic data Nature Communications
author_facet	Gengjie Jia Yu Li Hanxin Zhang Ishanu Chattopadhyay Anders Boeck Jensen David R. Blair Lea Davis Peter N. Robinson Torsten Dahlén Søren Brunak Mikael Benson Gustaf Edgren Nancy J. Cox Xin Gao Andrey Rzhetsky
author_sort	Gengjie Jia
title	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_short	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_full	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_fullStr	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_full_unstemmed	Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
title_sort	estimating heritability and genetic correlations from large health datasets in the absence of genetic data
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations for thousands of disease pairs.
url	https://doi.org/10.1038/s41467-019-13455-0
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data

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