Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell Lymphomagenesis

Dichotomous Impact of Myc on rRNA Gene Activation and Silencing in B Cell Lymphomagenesis

A major transcriptional output of cells is ribosomal RNA (rRNA), synthesized by RNA polymerase I (Pol I) from multicopy rRNA genes (rDNA). Constitutive silencing of an rDNA fraction by promoter CpG methylation contributes to the stabilization of these otherwise highly active loci. In cancers driven...

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Bibliographic Details
Main Authors: Gaurav Joshi, Alexander Otto Eberhardt, Lisa Lange, René Winkler, Steve Hoffmann, Christian Kosan, Holger Bierhoff
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
cancer
lymphomagenesis
Myc
ribosomal RNA
gene transcription
epigenetic regulation
Online Access:https://www.mdpi.com/2072-6694/12/10/3009

Internet

https://www.mdpi.com/2072-6694/12/10/3009

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