MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

Summary: Here, we report that MYC rescues early human cells undergoing reprogramming from a proliferation pause induced by OCT3/4, SOX2, and KLF4 (OSK). We identified ESRG as a marker of early reprogramming cells that is expressed as early as day 3 after OSK induction. On day 4, ESRG positive (+) ce...

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Bibliographic Details
Main Authors: Tim A. Rand, Kenta Sutou, Koji Tanabe, Daeun Jeong, Masaki Nomura, Fumiyo Kitaoka, Emi Tomoda, Megumi Narita, Michiko Nakamura, Masahiro Nakamura, Akira Watanabe, Eric Rulifson, Shinya Yamanaka, Kazutoshi Takahashi
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304029

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http://www.sciencedirect.com/science/article/pii/S2211124718304029

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