Advanced Oxidative Protein Products Cause Pain Hypersensitivity in Rats by Inducing Dorsal Root Ganglion Neurons Apoptosis via NADPH Oxidase 4/c-Jun N-terminal Kinase Pathways

Advanced Oxidative Protein Products Cause Pain Hypersensitivity in Rats by Inducing Dorsal Root Ganglion Neurons Apoptosis via NADPH Oxidase 4/c-Jun N-terminal Kinase Pathways

Pain hypersensitivity is the most common category of chronic pain and is difficult to cure. Oxidative stress and certain cells apoptosis, such as dorsal root ganglion (DRG) neurons, play an essential role in the induction and development of pain hypersensitivity. The focus of this study is at a more...

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Bibliographic Details
Main Authors: Ruoting Ding, Baihui Sun, Zhongyuan Liu, Xinqiang Yao, Haiming Wang, Xing Shen, Hui Jiang, Jianting Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
advanced oxidative protein products
hypersensitivity
apoptosis
oxidative stress
dorsal root ganglion
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00195/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00195/full

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