Early glycolytic reprogramming controls microglial inflammatory activation

Early glycolytic reprogramming controls microglial inflammatory activation

Abstract Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosphorylation to aerobic glycolysis. However, the rol...

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Bibliographic Details
Main Authors: Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Glycolytic inhibitors
Microglial cells
Neuroinflammation
NF-κB
2-DG
Online Access:https://doi.org/10.1186/s12974-021-02187-y

Internet

https://doi.org/10.1186/s12974-021-02187-y

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