Wwp2 maintains cartilage homeostasis through regulation of Adamts5

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that disease severity is reduced by injection of Wwp2 mRN...

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Bibliographic Details
Main Authors: Sho Mokuda, Ryo Nakamichi, Tokio Matsuzaki, Yoshiaki Ito, Tempei Sato, Kohei Miyata, Masafumi Inui, Merissa Olmer, Eiji Sugiyama, Martin Lotz, Hiroshi Asahara
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10177-1

Internet

https://doi.org/10.1038/s41467-019-10177-1

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