Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

<p>Abstract</p> <p>Background</p> <p>Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the <it>parkin</...

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Bibliographic Details
Main Authors: Imaizumi Yoichi, Okada Yohei, Akamatsu Wado, Koike Masato, Kuzumaki Naoko, Hayakawa Hideki, Nihira Tomoko, Kobayashi Tetsuro, Ohyama Manabu, Sato Shigeto, Takanashi Masashi, Funayama Manabu, Hirayama Akiyoshi, Soga Tomoyoshi, Hishiki Takako, Suematsu Makoto, Yagi Takuya, Ito Daisuke, Kosakai Arifumi, Hayashi Kozo, Shouji Masanobu, Nakanishi Atsushi, Suzuki Norihiro, Mizuno Yoshikuni, Mizushima Noboru, Amagai Masayuki, Uchiyama Yasuo, Mochizuki Hideki, Hattori Nobutaka, Okano Hideyuki
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Molecular Brain
Subjects:
Induced pluripotent stem cells
Parkinson’s disease
Parkin
Oxidative stress
Mitochondria
α-synuclein
Online Access:http://www.molecularbrain.com/content/5/1/35

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http://www.molecularbrain.com/content/5/1/35

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