The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.

Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study, we characterize SIRT2 inhibition activity of the...

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Bibliographic Details
Main Authors: Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B Silverman, Cenk Ayata, Michelle M Maxwell, Clemens Steegborn, Michael A Schwarzschild, Tiago F Outeiro, Aleksey G Kazantsev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4301865?pdf=render

Internet

http://europepmc.org/articles/PMC4301865?pdf=render

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