Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.

Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind impose severe topological constraints impedin...

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Bibliographic Details
Main Authors: Wareed Ahmed, Claudia Sala, Shubhada R Hegde, Rajiv Kumar Jha, Stewart T Cole, Valakunja Nagaraja
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5433769?pdf=render

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http://europepmc.org/articles/PMC5433769?pdf=render

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