Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation between induction of regulatory T cells (Treg) and tolerance to th...

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Bibliographic Details
Main Authors: Roland W. Herzog, Veronica Kuteyeva, Rania Saboungi, Cox Terhorst, Moanaro Biswas
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
hemophilia A
tolerance
FoxP3
treg
cell therapy
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00274/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00274/full

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