In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.

The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP4 can act as a soluble analog of the phosphoinositide 3-kina...

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Bibliographic Details
Main Authors: Sayak Mukherjee, Stephanie Rigaud, Sang-Cheol Seok, Guo Fu, Agnieszka Prochenka, Michael Dworkin, Nicholas R J Gascoigne, Veronica J Vieland, Karsten Sauer, Jayajit Das
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3774804?pdf=render

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http://europepmc.org/articles/PMC3774804?pdf=render

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