In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.
The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP4 can act as a soluble analog of the phosphoinositide 3-kina...
Main Authors: | Sayak Mukherjee, Stephanie Rigaud, Sang-Cheol Seok, Guo Fu, Agnieszka Prochenka, Michael Dworkin, Nicholas R J Gascoigne, Veronica J Vieland, Karsten Sauer, Jayajit Das |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3774804?pdf=render |
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