Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

The mechanisms underlying the transport of leptin into the brain are still largely unclear. While the leptin receptor has been implicated in the transport process, recent evidence has suggested an additional role of LRP2 (megalin). To evaluate the function of LRP2 for leptin transport across the blo...

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Bibliographic Details
Main Authors: Elvira S. Sandin, Julica Folberth, Helge Müller-Fielitz, Claus U. Pietrzik, Elisabeth Herold, Thomas E. Willnow, Paul T. Pfluger, Ruben Nogueiras, Vincent Prevot, Thomas Krey, Markus Schwaninger
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
leptin
blood-brain barrier
LRP2
ERK1/2
gaussia luciferase
fusion protein
Online Access:https://www.mdpi.com/1422-0067/22/9/4998

Internet

https://www.mdpi.com/1422-0067/22/9/4998

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