Therapeutic Editing of the <i>TP53</i> Gene: Is CRISPR/Cas9 an Option?

Therapeutic Editing of the <i>TP53</i> Gene: Is CRISPR/Cas9 an Option?

The <i>TP53</i> gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g., mutations of the <i>TP5...

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Bibliographic Details
Main Authors: Regina Mirgayazova, Raniya Khadiullina, Vitaly Chasov, Rimma Mingaleeva, Regina Miftakhova, Albert Rizvanov, Emil Bulatov
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Genes
Subjects:
<i>TP53</i>
mutation
CRISPR/Cas9 gene editing
base editing
prime editing
epigenome regulation
Online Access:https://www.mdpi.com/2073-4425/11/6/704

Internet

https://www.mdpi.com/2073-4425/11/6/704

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